High resolution pHe imaging of rat glioma using pH-dependent relaxivity
نویسندگان
چکیده
منابع مشابه
High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity.
Previous studies using MR spectroscopy have shown that the extracellular pH (pH(e)) of tumors is acidic compared to normal tissues. This has a number of important sequelae that favor the emergence of more aggressive and therapy-resistant tumors. New MRI methods based on pH-sensitive T1 relaxivity are an attractive alternative to previous spectroscopic methods, as they allow improvements in spat...
متن کاملHigh Spatio-Temporal Resolution pHe Mapping of a Rat Glioma Derived From pH-Dependent Spin-Lattice Relaxivity
Introduction The extracellular pH (pHe) of cancers is acidic and inhibiting this acidity will inhibit metastases. Methods to image pHe in tumors based on relaxivity of a pH-dependent contrast reagent (CR), Gd-DOTA-4AmP were developed. We investigated the single injection of a mixture of DyDOTP with GdDOTA-4AmP. The ΔT1, and ΔT2* induced by the Gd-CR exhibited similar pH-dependence, while the pH...
متن کاملHigh-Resolution pH Imaging of Living Bacterial Cells To Detect Local pH Differences
Protons are utilized for various biological activities such as energy transduction and cell signaling. For construction of the bacterial flagellum, a type III export apparatus utilizes ATP and proton motive force to drive flagellar protein export, but the energy transduction mechanism remains unclear. Here, we have developed a high-resolution pH imaging system to measure local pH differences wi...
متن کاملHigh-resolution imaging of vessels in the isolated rat brain
Introduction: While several atlases are available depicting the spatial distribution of various parameters either measured with MRI or from histological section, no comparable comprehensive data exists for the distribution of vessels in the rat brain. Angiography is able to use the blood flow in the brain of the living rat to display the largest arteries, while SWI can visualize veins down to m...
متن کاملMultimodal targeted high relaxivity thermosensitive liposome for in vivo imaging
Liposomes are spherical, self-closed structures formed by lipid bilayers that can encapsulate drugs and/or imaging agents in their hydrophilic core or within their membrane moiety, making them suitable delivery vehicles. We have synthesized a new liposome containing gadolinium-DOTA lipid bilayer, as a targeting multimodal molecular imaging agent for magnetic resonance and optical imaging. We sh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2006
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.20773